Detalhe da pesquisa
1.
Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance.
Proc Natl Acad Sci U S A
; 121(9): e2312987121, 2024 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38377214
2.
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
Antimicrob Agents Chemother
; 67(10): e0056723, 2023 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37702508
3.
Structure-Activity relationships of replacements for the triazolopyridazine of Anti-Cryptosporidium lead SLU-2633.
Bioorg Med Chem
; 86: 117295, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148788
4.
Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection.
Antimicrob Agents Chemother
; 65(12): e0146021, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516242
5.
Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530599
6.
Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy.
J Pharmacol Exp Ther
; 370(2): 219-230, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31189728
7.
Troponoids Can Inhibit Growth of the Human Fungal Pathogen Cryptococcus neoformans.
Antimicrob Agents Chemother
; 61(4)2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28167553
8.
Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors.
Biochemistry
; 55(5): 809-19, 2016 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26829613
9.
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.
J Pharmacol Exp Ther
; 357(2): 423-31, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26907621
10.
Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugates.
Bioorg Med Chem
; 24(16): 3527-39, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27298002
11.
Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.
Antimicrob Agents Chemother
; 59(2): 1070-9, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25451058
12.
The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.
PLoS Pathog
; 9(1): e1003125, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23349632
13.
Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents.
Bioorg Med Chem
; 23(16): 5144-50, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25797165
14.
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
bioRxiv
; 2023 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37205554
15.
The anti-cancer efficacy of a novel phenothiazine derivative is independent of dopamine and serotonin receptor inhibition.
Front Oncol
; 13: 1295185, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37909019
16.
Comparative chemical genomics in Babesia species identifies the alkaline phosphatase phoD as a novel determinant of resistance.
bioRxiv
; 2023 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398106
17.
Structure-Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine.
J Med Chem
; 66(12): 7834-7848, 2023 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37267631
18.
MEPicides: α,ß-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase.
ACS Infect Dis
; 9(7): 1387-1395, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37310810
19.
Quinine bis-conjugates with quinolone antibiotics and peptides: synthesis and antimalarial bioassay.
Org Biomol Chem
; 10(45): 8985-93, 2012 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23070233
20.
Repurposing and optimization of drugs for discovery of novel antifungals.
Drug Discov Today
; 27(7): 2008-2014, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35489676